The failure to discover a significant new class of insecticides has led many researchers back to biodiscovery studies in the search for new and economically viable alternatives. After a preliminary screening of botanical extracts using descending series of concentrations (1,000, 500, 100, 50, and 5 mg/liter), 8 extracts from 2 potential botanical agents, Khaya senegalensis (Desrousseaux) and Daucus carota L., were tested against 4th instars of Culex annulirostris (Skuse) following the standard World Health Organization insecticide susceptibility methodology. The median lethal concentration (LC₅₀) values for K. senegalensis against Cx. annulirostris using acetone, ethanol, hexane, and methanol extracts were 20.12, 5.1, 5.08, and 7.62 mg/liter, respectively. The LC₅₀ values for D. carota against Cx. annulirostris using acetone, ethanol, hexane, and methanol extracts were 236.00, 36.59, 77.19, and 241.8 mg/liter, respectively. Extracts from K. senegalensis were more potent than those from D. carota against Cx. annulirostris and hexane and ethanol were the best solvents to extract essential oils from both plant species, respectively. In potency, K. senegalensis was similar to azadirachtin, but fractionation and compound isolation of the hexane extract in particular may reveal a potent phytochemical that could be compared to synthetic mosquitocides.